Ref: 80912
The Wellcome Trust Sanger Institute is a world leader in genomic research, with an expanding scientific programme dedicated to understanding gene function in health & disease.
A postdoctoral position is available in Computational Genomics at the Wellcome Trust Sanger Institute under the leadership of Dr Daniel Gaffney. The long-term goal of the lab is to understand how genetic change influences gene regulation, using a combination of statistical and experimental approaches. The specific project is flexible, and the successful applicant will be expected to develop their own interests, but current research themes include
(i) Regulatory and gene expression variation in humans
(ii) The impact of regulatory change on disease susceptibility and evolution
(iii) Comparative genomics and molecular evolution of gene regulatory regions
We welcome candidates with a background in Biology and strong quantitative skills. Candidates from Physics, Statistics or Computer Science with strong interests in computational biology and/or population genetics are also encouraged to apply. Excellent programming skills, experience with very large data sets and an ability to work as part of a team are essential. Our lab also has access to wet-lab facilities and personnel - as part of their research, the successful candidate will also have the opportunity to generate novel high-throughput data sets and to test hypotheses in an experimental setting.
Essential Skills
- PhD in a relevant subject area (Computational Biology, Population Genetics/Genomics, Computer Science, Physics
- Excellent programming skills (C, C++, Perl, Python, or R)
- Strong statistical and quantitative skills
- Ability to communicate ideas and results effectively
- Ability to work well with other team members
- Independent research goals and objectives
Ideal Skills
- Experience with analysis of -omics data sets
- Previous experience with genetics of gene regulation, QTL analysis
Other information
Although genetic variation in gene regulation is thought to play an important role in evolution and disease, the pathway from regulatory mutation, via gene expression to phenotype is still poorly understood. Understanding this pathway will be an essential component in the application of genomics to personalized medicine. The Sanger Centre offers a world-class academic environment, access to cutting edge sequencing facilities and extensive expertise in genome analysis and human genetics. As such, we are in a prime position to begin to address some of these fundamental questions. The ultimate goal of our lab is to be able to predict the impact of new mutations on gene regulation and to understand how such changes impact phenotype. To achieve this, we combine of sequence and genome analysis, comparative genomics and population level, expression QTL-mapping.
Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. Successful applicant(s) who have submitted their PhD thesis and are awaiting their PhD award to be confirmed will be placed on a transitional pay point, currently £26,103. On confirmation applicants will be moved on to the pay scale above.
This position is initially for a fixed term of 3 years. For further information please contact Caren Brockington on cb13@sanger.ac.uk
Benefits
The Institute has excellent purpose built facilities on the Genome Campus, Hinxton on the outskirts of Cambridge. We offer a comprehensive range of benefits including a final salary pension scheme and excellent on-site facilities. Further details can be found on our website https://jobs.sanger.ac.uk,
Salary range £28,280 to £347,78 dependent on experience.
Closing Date: 29th July 2011
To submit your CV and apply for this job please go to https://jobs.sanger.ac.uk, to register and apply on line.
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